Best For: An All-Around Glow

This beauty editor-favorite serum is beloved for its multitasking results. “The combination of superior antioxidants vitamins C and E with ferulic acid provides an incomparable serum,” says Dr. Schlessinger. The jam-packed formula works to brighten, tighten and protect skin of all ages.

SkinCeuticals C E Ferulic Antioxidant Serum ($166)

Best For: Fighting Lines and Wrinkles

“The science and ongoing research behind DefenAge 8-in-1 BioSerum is remarkable,” says Dr. Schlessinger. The “eight” in the name comes from all the ways this serum targets anti-aging, including smoothing fine lines, lifting the face and soothing skin.

 DefenAge 8-in-1 BioSerum ($165)

Best For: Building Collagen

If you’ve noticed skin laxity or sagging in newfound areas of the face, this is the serum to add to your routine. It’s formulated to boost collagen—the tissue that makes for tight, bouncy skin—with noticeable results in two weeks. It’s also fragrance-free, so sensitive skin types don’t need to worry about irritation.

SkinMedica TNS Advanced+ Serum ($295)

Best For: Thirsty Skin

Hyaluronic acid is the multivitamin of skin-care ingredients—every single one of us can use it. Whether you deal with dry skin or just want a little more nourishment, Dr. Schlessinger says this serum “instantly hydrates skin ad provides long-term anti-aging benefits.”

PCA SKIN Hyaluronic Acid Boosting Serum ($115)

Best For: Tackling Dark Spots

Sunspots and hyperpigmentation are some of the most stubborn skin conditions, but this potent antioxidant serum will get your skin on the road to recovery. Its 20-percent concentration of L-ascorbic acid protects skin against free-radical damage while lightening existing spots, so you’ll have bright skin now and later.

Obagi Professional-C Serum 20% ($127)

Best For: Skin Rejuvenation

“Cellular Anti-Aging Peptide Serum is great for all skin types and contains an incredible array of actives, including peptides and hyaluronic acid,” says Dr. Schlessinger. This serum addresses skin aging head on with a formula that works to promote more youthful-looking skin. It’s formulated for all skin types, so anyone who needs a boost of anti-aging can safely add it to their routine.

LovelySkin LUXE Cellular Anti-Aging Peptide Serum ($125)

Best For: Overall Anti-Aging

This potent serum uses growth factors and peptides to rejuvenate aging skin. It’s been proven to show results in just six days, and yes, that means less noticeable fine lines in less than a week.

Neocutis Bio Serum Firm Rejuvenating Growth Factor & Peptide Treatment ($275)

Best For: Hormonally Challenged Skin

“No other company offers such a novel and innovative approach to female skin rejuvenation,” says Dr. Schlessinger. “Emepelle provides an excellent non-hormonal answer to Estrogen Deficient Skin with this advanced serum.” This highly targeted serum is a must-add for women nearing or past menopause.

Emepelle Serum ($175)

Best For: Rough Skin

This dermatologist-developed Intense Defense Serum is a veritable alphabet soup of powerful ingredients, with its potent combination of vitamins A, B, C, D and E. Together with botanical extracts, the serum works to soften skin texture and firm fine lines.

Epionce Intense Defense Serum ($144)

Best For: Damaged Skin

“This serum provides great anti-aging benefits, but it even addresses conditions like rosacea, cystic acne and certain forms of dermatitis,” says Dr. Schlessinger. It pairs retinol with vitamin C for a double-dose of protection.

iS CLINICAL Pro-Heal Serum Advance+ ($155)